Handles are valid only in the application domain in which they were obtained.

A RuntimeMethodHandle structure for a constructor or method of a generic type can represent different System.Reflection.MethodBase objects, depending on the types specified for the type parameters of the generic type. For example, if class G<T> (class G(Of T) in Visual Basic, generic <T> ref class G in C++) has a method that returns type T, the System.Reflection.MethodBase object for that method in a constructed class such as G<int> is different from the System.Reflection.MethodBase object for that method in the generic type definition.