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The ProcessModelSection.Enable property specifies whether ASP.NET is hosted in an external worker process. If ProcessModelSection.Enable is true, ASP.NET is hosted in an external worker process; otherwise, it runs directly in Inetinfo.exe.
Running ASP.NET in Inetinfo.exe is not recommended, because this involves running the application in the Local System security context. When ASP.NET runs in Internet Information Services (IIS) 6 native mode, this setting is ignored, so there is usually no reason to set it to false.