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The configuration file describes the search rules and configuration data for the application domain. The host that creates the application domain is responsible for supplying this data because the meaningful values vary from situation to situation.
For example, the configuration data for ASP.NET applications is stored for each application, site, and computer, while the configuration data for an executable is stored for each application, user, and computer. Only the host knows the specifics of the configuration data for a particular circumstance.
This property cannot be changed after the AppDomain has finished its first bind.